Table 3 Performance of F-CAD against WHO's Target Product Profile by reference
Reference | Xpert results | "abnormality suggestive of TB" | "any abnormality in the lung fields" | |
|---|---|---|---|---|
Sensitivity≧95 | Actual sensitivity | 0.954 (0.902–0.983) | 0.951 (0.931–0.967) | 0.950 (0.938–0.961) |
TB score | 0.72 | 0.36 | 0.15 | |
Specificity (95%CI) | 0.517 (0.488–0.545) | 0.747 (0.737–0.757) | 0.525 (0.513–0.537) | |
Sensitivity≧90 | Actual sensitivity | 0.900 (0.835–0.946) | 0.901 (0.874–0.923) | 0.900 (0.884–0.915) |
TB score | 0.88 | 0.53 | 0.28 | |
Specificity (95%CI) | 0.621 (0.594–0.648) | 0.844 (0.835–0.852)* | 0.750 (0.739–0.760)* | |
Specificity≧80 | Actual specificity | 0.800 (0.777–0.822) | 0.800 (0.791–0.809) | 0.800 (0.790–0.809) |
TB score | 0.97 | 0.44 | 0.34 | |
Sensitivity (95%CI) | 0.715 (0.630–0.791) | 0.930 (0.907–0.949) | 0.879 (0.862–0.895) | |
Specificity≧70 | Actual specificity | 0.700 (0.674–0.726) | 0.700 (0.690–0.710) | 0.700 (0.689–0.711) |
TB score | 0.93 | 0.31 | 0.25 | |
Sensitivity (95%CI) | 0.854 (0.854–0.910) | 0.964 (0.946–0.977)* | 0.914 (0.899–0.928) | |