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Table 2 Frequency of genetic alleles potentially linked to malaria resistance to anti-folate drugs in the DRC

From: The landscape of drug resistance in Plasmodium falciparum malaria in the Democratic Republic of Congo: a mapping systematic review

Alleles

n*

m*

Median % of mutants (IQR)

PfDHPS alleles

   

 I431V

1588

14

1.4 (0.9)

 S436A

2165

297

7.4 (13.9)

 A437G

2103

1821

88.0 (33.6)

 K540E

3518

1373

38.9 (47.7)

 A581G

3076

431

10.7 (17.7)

 A613S

1684

10

0.1 (0.5)

PfDHFR alleles

   

 N51I

2324

2260

97.9 (25.0)

 C59R

2324

1937

79.1 (0.0625)

 S108N

2324

2291

99.5 (11.9)

 I164L

2927

2

 < 0.1 (3.94)

  1. (*) n: no. of genotyped isolates; m: no. of detected mutants