Fig. 4

Distribution of Plasmodium parasites carrying PfK13 mutations potentially linked to artemisinin (ART) resistance in the DRC. Each circle shown on this map reflects a survey that reported at least one malaria parasite carrying a mutation onto a PfK13’s locus that is validated or suspected for driving ART resistance. The diameter of circles is proportional to the number of isolates for which the PfK13 sequence has been successfully genotyped. Mutations are shown with absolute frequencies across different surveyed sites. Unshaded areas reflect provinces that have been monitored for parasites harboring PfK13 mutations (i.e., Haut-Katanga: 3; Lualaba: 4; Kasai-Central: 8; Kinshasa:10; Kwilu: 13; Lualaba: 15; Maniema: 17; Nord-Kivu: 19; Nord-Ubangi: 20; Sud-Kivu: 22; Tshopo: 25; and Tshuapa: 26)