Tropical Medicine and Health

Table 6 Clinical predictors associated with mortality in patients with CNS NTM infection

From: Epidemiology, clinical presentation, and predictors of outcome in nontuberculous mycobacterial central nervous system infection: a systematic review

Variable	Univariate analysis			Multivariate analysis
Variable	Mortality rate (%)	p value	Crude OR (95% CI)	p value	Crude OR (95% CI)
Age
≥ 65 (years)	63.6	0.039	4.1, (1.2–17.2)	0.198	1.8, (0.32–3.2)
< 65	34.7	0.039	4.1, (1.2–17.2)	0.198	1.8, (0.32–3.2)
Male	46.5	0.011	3.3, (1.2–7.3)	0.025	2.4, (1.2–7.9)
Female	21.9	0.011	3.3, (1.2–7.3)	0.025	2.4, (1.2–7.9)
HIV	57.9	0.002	3.4, (1.5–7.9)	0.017	3.7, (1.8–6.1)
Non-HIV	27.4	0.002	3.4, (1.5–7.9)	0.017	3.7, (1.8–6.1)
Disseminated NTM	50	0.044	2.4, (1.1–5.4)	0.181	1.5, (0.45–6.5)
Isolated CNS NTM	28.8	0.044	2.4, (1.1–5.4)	0.181	1.5, (0.45–6.5)
MAC infection	47.4	0.149	1.2, (0.82–4.1)
Non-MAC NTM	32.4	0.149	1.2, (0.82–4.1)
M. fortuitum infection	4.1	< 0.001	0.05, (0.01–0.38)	0.012	0.18, (0.08–0.45)
Other NTM	46.6	< 0.001	0.05, (0.01–0.38)	0.012	0.18, (0.08–0.45)
CSF protein
≥ 60 mg/dl	63.3	0.011	3.8, (2.1–28.9)	0.091	2.3, (0.56–23.1)
< 60	18.2	0.011	3.8, (2.1–28.9)	0.091	2.3, (0.56–23.1)

OR = Odds ratio, CI = Confidence interval, p value < 0.05 considered significant

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