Table 3 Predictive factors of incidence of CVD in Kharameh population according to multivariable Cox regression with Firth's bias reduction method analysis
Variable | Class | Simple Cox regression | Multiple Cox regression | ||
|---|---|---|---|---|---|
HR (95%CI) | p value* | HRadj (95%CI) | p value* | ||
Age | 40–50 | 1 | 1 | ||
50–60 | 3.2 (2.4,4.2) | < 0.01 | 2.4 (1.8,3.3) | < 0.01 | |
60–70 | 5.7 (4.3,7.6) | 3.7 (2.7,5.2) | |||
Sex | Female | 1 | 1 | ||
Male | 2.02 (1.6,2.4) | < 0.01 | 2.3 (1.7,3.2) | < 0.01 | |
Having Job | No | 1 | 1 | ||
Yes | 1.2 (1.05,1.5) | 0.013 | 1.1 (0.9,1.5) | 0.2 | |
Married status | Single | 1 | 0.001 | 1 | 0.32 |
Married | 4.4 (0.8,22.3) | 1.6 (0.3,8.4) | |||
Divorced | 6.5 (0.28,33.4) | 2.3 (0.4,12) | |||
Socioeconomic status | Low | 1 | 0.55 | – | |
Moderate | 1.1 (0.84,1.44) | – | |||
High | 0.93 (0.69,1.25) | – | |||
Very high | 0.93 (0.69,1.24) | – | |||
Education | Illiterate | 1 | < 0.01 | 1 | 0.39 |
Primary school | 0.5 (0.4,0.7) | 0.7 (0.5,1.02) | |||
Secondary school | 0.6 (0.4,0.9) | 0.8 (0.58,1.2) | |||
Diploma and University | 0.5 (0.3,0.7) | 0.6 (0.45,1.01) | |||
BMI | Under weight | 1 | 0.6 | – | |
Normal | 1.36 (0.78,2.37) | – | |||
Over weight | 1.07 (0.61,1.88) | – | |||
Obese | 0.93 (0.51,1.7) | – | |||
Location | Urban | 1 | 1 | ||
Rural | 0.8 (0.6,1.07) | 0.19 | 0.8 (0.6,1.5) | 0.1 | |
Chronic kidney disease | No | 1 | 1 | ||
Yes | 3.7 (1.4,9.4) | < 0.01 | 3.4 (1.3,8.7) | 0.02 | |
Hypertension | No | 1 | 1 | ||
Yes | 2.1 (1.7,2.6) | < 0.01 | 1.6 (1.3–2.1) | < 0.01 | |
Diabetes mellitus | No | 1 | 1 | ||
Yes | 2.8 (2.3,3.5) | < 0.01 | 2.3 (1.8,2.9) | < 0.01 | |
Fatty liver | No | 1 | – | ||
Yes | 0.82 (0.58,1.16) | 0.27 | – | ||
Alcohol consumption | No | 1 | 1 | ||
Yes | 1.8 (1.2,2.5) | 0.001 | 1.5 (1.09,2.2) | < 0.01 | |
Cigarette smoking | No | 1 | 1 | ||
Yes | 1.7 (1.3,2.1) | < 0.01 | 1.2 (0.9,1.6) | 0.05 | |
LDL | 1.003 (1.002,1.004) | < 0.01 | 1.003 (1.002,1.003) | < 0.01 | |
TG | 1.001 (1.0003,1.002 | < 0.01 | 1.006 (0.99,1.001) | 0.4 | |
FBS | 1.005 (1.003–1.007) | < 0.01 | 1.002 (0.99,1.004) | 0.08 | |
Hip circumference | 0.9 (0.9,0.9) | < 0.01 | 0.9 (0.9,1.01) | 0.1 | |
Waist circumference | 1.005 (0.99,1.01) | 0.17 | – | ||