Compound | Babesia and Theileria | IC50 (μM)a | EC50 (μM)b | Selective indicesc |
---|
MDBK | NIH/3 T3 | HFF | MDBK | NIH/3 T3 | HFF |
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IVM | B. bovis | 53.3 ± 4.8 | 138.9 ± 4.9 | 283.8 ± 3.6 | 287.5 ± 7.6 | 2.6 | 5.3 | 5.4 |
B. bigemina | 98.6 ± 5.7 | 138.9 ± 4.9 | 283.8 ± 3.6 | 287.5 ± 7.6 | 1.4 | 2.9 | 2.9 |
B. divergens | 30.1 ± 2.2 | 138.9 ± 4.9 | 283.8 ± 3.6 | 287.5 ± 7.6 | 4.6 | 9.4 | 9.6 |
B. caballi | 43.7 ± 3.7 | 138.9 ± 4.9 | 283.8 ± 3.6 | 287.5 ± 7.6 | 3.2 | 6.5 | 6.6 |
T. equi | 90.1 ± 8.1 | 138.9 ± 4.9 | 283.8 ± 3.6 | 287.5 ± 7.6 | 1.5 | 3.1 | 3.2 |
- aHalf-maximal inhibition concentration of ivermectin on the in vitro culture of parasites. The value was determined from the dose-response curve using nonlinear regression (curve fit analysis). The values are the means of triplicate experiments
- bHalf-maximal effective concentration of ivermectin on cell lines. The values were determined from the dose-response curve using nonlinear regression (curve fit analysis). The values are the means of triplicate experiments
- cRatio of the EC50 of cell lines to the IC50 of each species. High numbers are favorable
- IVM ivermectin, MDBK Madin–Darby bovine kidney, NIH/3 T3 Mouse embryonic fibroblast, HFF Human foreskin fibroblast