Table 1 Pharmacokinetic parameters of N-251 after intravenous administration in mice
From: Pharmacokinetic analysis of new synthetic antimalarial N-251
Dose (mg/kg) | Pharmacokinetic parameters | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
AUCiv (ng/mL·h) | CLtotal (L/h/kg) | kel (h−1) | Vd1 (L/kg) | Vd2 (L/kg) | Vdss (L/kg) | MRTiv (h) | A (ng/mL) | a (h−1) | B (ng/mL) | b (h−1) | |
5 | 1161.50 | 4.30 | 1.33 | 3.23 | 1.62 | 4.85 | 1.12 | 1453.6 ± 465.9 | 1.62 ± 0.70 | 92.5 ± 182.0 | 0.35 ± 0.37 |
10 | 2433.64 | 4.11 | 2.60 | 1.58 | 2.35 | 3.93 | 0.96 | 5922.7 ± 1731.5 | 3.84 ± 1.23 | 410.0 ± 253.8 | 0.46 ± 0.15 |
25 | 7455.60 | 3.35 | 2.47 | 1.36 | 1.52 | 2.88 | 0.86 | 17,738.1 ± 1700.0 | 3.12 ± 0.55 | 690.4 ± 341.6 | 0.39 ± 0.10 |