Drug/dose, mg | CT (mean ± SD) | Parasite load | P value |
---|---|---|---|
KET | |||
2 | 28.26 ± 0.77 | 15,698 | P < 0.001 |
3 | 24.53 ± 0.06 | 72,898 | P < 0.001 |
KET and PYR | |||
2 + 50 | 23.37 ± 1.15 | 100,597 | P < 0.001 |
3 + 50 | 22.42 ± 1.39 | 196,591 | P < 0.001 |
PYR (positive control) | |||
50 | 25.28 ± 0.82 | 30,572 | P < 0.001 |
PBS (negative control) | 21.12 ± 0.34 | 865,548 | – |