Table 4 Parasite ligands, host receptors, and clinical consequences [61–63]
Receptor | PfEMP1 domain | Clinically significant |
|---|---|---|
CD36 | CIDR1α | Uncomplicated/severe malaria |
ICAM-1 | DBL2/β type | Cerebral malaria |
CSA | DBL3/γ type, CIDR1α | Placental infection and other forms |
HS | DBL1α | RBC rosette formation |
CR1 | DBL1α | Rosette/immune complex formation/parasite invasion |
CD31/PECAM | CIDR1α, DBL2/δ type | Virulence-associated endothelial receptor |