Table 2 Characteristic of P. berghei ANKA strain in mouse model and P. falciparum in humans for CM study
Characteristics | P. berghei ANKA model | Human CM |
|---|---|---|
Stage of sequestration | Schizonts | Mature trophozoites, schizonts, mature gametocytes |
Host cell adhesion molecule | CD36 | CD36, ICAM-1, PCAM-1/CD31, CR1, CSA |
Parasite ligand | No homologous protein of PfEMP1 | PfEMP1 |
Site for sequestration | Brain, lung, spleen, adipose tissue | Brain, lung, spleen, intestine, bone marrow, skin, skeletal and cardiac muscle, and adipose tissue |
Brain hemorrhage | ++ | ++ |
Obstruction of microvessels | +++ | +++ |
Sequestration of infected RBC | + | +++ |
Knobs on infected RBC | − | ++ |