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Table 1 IC50 and CC50 values of 5-ALA and 5-ALA with SFC against SARS-CoV-2 Omicron variant

From: 5-Aminolevulinic acid antiviral efficacy against SARS-CoV-2 omicron variant in vitro

SARS-CoV-2 variants* Compound IC50 (µM) CC50 (µM)
Wuhan 5-ALA 207  > 2000
  5-ALA/SFC 235/58.7  > 2000/ > 500
Alpha 5-ALA 104  > 2000
  5-ALA/SFC 173/43.2  > 2000/ > 500
Beta 5-ALA 1592  > 2000
  5-ALA/SFC 1311/327.7  > 2000/ > 500
Gamma 5-ALA  > 2000  > 2000
  5-ALA/SFC 1516/379  > 2000/ > 500
Delta 5-ALA  > 2000  > 2000
  5-ALA/SFC 397/99.2  > 2000/ > 500
Omicron 5-ALA 329  > 2000
  5-ALA/SFC 765/191  > 2000/ > 500
  1. IC50 and CC50 of SARS-CoV-2* variants (Wuhan, Alpha, Beta, Gamma and Delta) was shown in our previous study
  2. In 5-ALA/SFC compound, the ratio of 5-ALA to SFC was fixed as 4:1
  3. IC50 50% inhibition concentration, CC50 50% cytotoxicity concentration, 5-ALA 5-aminolevulinic acid, SFC sodium ferrous citrate
  4. Bold text indicated IC50 and CC50 of Omicron variant in this study