Pharmacokinetic analysis of new synthetic antimalarial N-251

Table 2 Pharmacokinetic parameters of N-251 after oral administration in mice

Dose (mg/kg)	Pharmacokinetic parameters
Dose (mg/kg)	C_max (ng/mL)	T_max (h)	AUC_po (ng/mL·h)	F	MRT_po (h)
30	633.67 ± 128.70	2	1574.04	0.2156	2.45
50	1363.67 ± 798.98	2	2566.96	0.2110	2.49
68	1677.33 ± 811.23	2	3768.25	0.2277	2.46
100	2456.17 ± 802.04	2	5886.16	0.2419	2.46
210	4890.00±1188.24	2	15241.40	0.2982	2.74

C_max with SD and T_max are observed values. The AUC and MRT were calculated from 0 to infinity using the trapezoidal rule. F was calculated utilizing the AUC value of 2433.64 ng/mL·h, after intravenous administration of 10 mg/kg

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