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Table 2 Pharmacokinetic parameters of N-251 after oral administration in mice

From: Pharmacokinetic analysis of new synthetic antimalarial N-251

Dose (mg/kg) Pharmacokinetic parameters
Cmax (ng/mL) Tmax (h) AUCpo (ng/mL·h) F MRTpo (h)
30 633.67 ± 128.70 2 1574.04 0.2156 2.45
50 1363.67 ± 798.98 2 2566.96 0.2110 2.49
68 1677.33 ± 811.23 2 3768.25 0.2277 2.46
100 2456.17 ± 802.04 2 5886.16 0.2419 2.46
210 4890.00±1188.24 2 15241.40 0.2982 2.74
  1. Cmax with SD and Tmax are observed values. The AUC and MRT were calculated from 0 to infinity using the trapezoidal rule. F was calculated utilizing the AUC value of 2433.64 ng/mL·h, after intravenous administration of 10 mg/kg