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Table 1 Pharmacokinetic parameters of N-251 after intravenous administration in mice

From: Pharmacokinetic analysis of new synthetic antimalarial N-251

Dose (mg/kg) Pharmacokinetic parameters
AUCiv (ng/mL·h) CLtotal (L/h/kg) kel (h−1) Vd1 (L/kg) Vd2 (L/kg) Vdss (L/kg) MRTiv (h) A (ng/mL) a (h−1) B (ng/mL) b (h−1)
5 1161.50 4.30 1.33 3.23 1.62 4.85 1.12 1453.6 ± 465.9 1.62 ± 0.70 92.5 ± 182.0 0.35 ± 0.37
10 2433.64 4.11 2.60 1.58 2.35 3.93 0.96 5922.7 ± 1731.5 3.84 ± 1.23 410.0 ± 253.8 0.46 ± 0.15
25 7455.60 3.35 2.47 1.36 1.52 2.88 0.86 17,738.1 ± 1700.0 3.12 ± 0.55 690.4 ± 341.6 0.39 ± 0.10
  1. Pharmacokinetic parameters were calculated using the equations described in the “Methods” section. A, B, a, and b are hybrid parameters in the equation describing the plasma concentration-time profile after intravenous administration, and they were expressed as SD