Table 2 List of reported cases of severe malaria with PADH following oral arthemeter-lumefantrine therapy
Author | Age/sex | Ethnicity | Malaria type | Infection site | Previous malaria | Regimen | Parasitemia (% or/μL) | Peak LDH (IU/L) | Parasitemia clearance | Hb nadir (g/dL) | Blood transfusion | Coombs (direct/indirect) | Corticosteroid use | Result | Recurrence of PADH |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corpolongo et al. (2012) [11] | 34 M | Italian | Pf | Africa | No | IVQ + DOXY → AL | 6 | 2071 | Yes (72 h) | 5.9 (day 17) | Yes | Neg/Neg | No | Recovery | No |
De Nardo et al. (2013) [12] | 55 M | ND | Pf | Africa | Yes (30yrs ago) | AL | 6 | 1326 | Yes (48 h) | 6.9 (day 8,22) | Yes | Pos/Neg | Yes | Recovery | No |
Raffray et al. (2014) [13] | 17 F | Ivoirian | Pf | Africa | No | AL → IVAS | 0.8 | 658 | Yes (< 192 h) | 4.6 (day 14) | No | Pos/ND | Yes | Recovery | No |
Tsuchido et al. (2017) [14] | 20 M | Japanese | Pf | Africa | No | AL | 20.6 (865,000) | 1855 | Yes (96 h) | 7.2 (day 16) | No | Neg/Neg | No | Recovery | No |
27 F | Japanese | Pf | Africa | No | QH + DOXY → IVQG → AL | 7.9 | 712 | Yes (72 h)* | 8.8 (day 11) | No | Neg/ND | No | Recovery | No | |
Lebrun et al. (2017) [15] | 43 M | Caucasian | Pf | Africa | Yes (22yrs ago) | IVAS → AL | 30 | 3035 | Yes (72 h) | 5.3 (day 18) | No | Pos/Neg | Yes | ND | No |
Hasegawa et al. (2018) [16] | 21 M | Japanese | Pf + Pv | India | No | AL → MQ → CQ + PQ | 31.9 (920,000) | 1400 | Yes (48 h) | 3.8 (day 9) | Yes | Neg/Neg | No | Recovery | No |
Nakamura-Uchiyama et al. (2018) [17] | 41 M | Nigerian | Pf | Africa | ND | AL | (672,000) | ND | Yes (48 h) | 6.3 (day 19) | No | ND/ND | ND | ND | ND |
39 M | Japanese | Pf | Africa | ND | AL | (549,000) | ND | Yes (192–336 h) | 6.5 (day 18) | No | ND/ND | ND | ND | ND | |
Conlon et al. (2020) [18] | 24 M | ND | Pf | Africa | No | IVQD + DOXY → AL | 12 | 1759 | Yes (> 96 h)* | < 7 | Yes | Pos/ND | No | Recovery | ND |
Gustafsson et al. (2021) [19] | 60 F | ND | Pf | Africa | No | AL | ND | 925 | ND | < 4.3 | No† | Pos/ND | Yes | Death | − |
Kamegai et al. (2023) | 30sF | Japanese | Pf | Africa | No | IVQG → AL | 7.3 | 2394 | Yes (96 h) | 6.2 (day 17) | Yes | Neg/Neg | No | Recovery | No |