Fig. 2

Schematic representation of the DENV genome: A ORFs showing structural proteins (C-prM-E) and NS proteins (NS1–NS2AB–NS3–NS4AB–NS5) and 5′ and 3′ UTRs. Positions of complementary sequences are indicated by solid lines for 5′–3′CS and dashed lines for 5′–3′UAR. B Predicted secondary structure of the 5′ UTR of the genome. Structural elements of the 5′ terminal region include stem loop A (SLA), stem loop B (SLB), oligo (U) track spacer, translation initiator AUG, capsid region hairpin (cHP), and 5′ CS element. C Predicted representation of RNA elements at the 3′UTR of the genome. Predicted secondary structures of three defined domains are shown: domain I (variable region, VR), domain II (dumbbell structure, DB1 and DB2), and domain III (conserved sequences CS1 and 3′SL). In addition, the respective positions and sequences of the conserved elements corresponding to RCS2, CS2, 3′CS and 3′UAR are indicated [76]