Skip to main content

Table 1 IC50, and CC50, of different compounds on T. cruzi (Trypo: trypomastigote, Ama: amastigote, Epi: epimastigote) and mammalian cell (NMH, HuH28) lines

From: Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents

Cells

T. cruzi Trypo + Ama

T. cruzi Intracell Ama

T. cruzi Epi

NMH

HuH28

Assay

Luciferase activity

AlamarBlue viability

 

IC50 (ÎĽM)

CC50 (ÎĽM)

Coptisine chloride

4.48

4.98

15.1

> 40

> 100

Dehydrocorydaline nitrate

3.47

7.89

17.3

> 40

> 100

Palmatine chloride

2.66

17.4

22.3

> 40

> 100

Epiberberine chloride

> 40

> 40

NT

> 40

> 100

Berberrubine chloride

20.1

33.5

NT

> 40

> 100

dl-Tetrahydro coptisine

> 40

> 40

NT

> 40

> 100

Benznidazole

2.78

4.91

3.78

> 40

> 100

  1. Each experiment was repeated three times and representative data were shown