From: Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents
Cells | T. cruzi Trypo + Ama | T. cruzi Intracell Ama | T. cruzi Epi | NMH | HuH28 |
---|---|---|---|---|---|
Assay | Luciferase activity | AlamarBlue viability | |||
 | IC50 (μM) | CC50 (μM) | |||
Coptisine chloride | 4.48 | 4.98 | 15.1 | > 40 | > 100 |
Dehydrocorydaline nitrate | 3.47 | 7.89 | 17.3 | > 40 | > 100 |
Palmatine chloride | 2.66 | 17.4 | 22.3 | > 40 | > 100 |
Epiberberine chloride | > 40 | > 40 | NT | > 40 | > 100 |
Berberrubine chloride | 20.1 | 33.5 | NT | > 40 | > 100 |
dl-Tetrahydro coptisine | > 40 | > 40 | NT | > 40 | > 100 |
Benznidazole | 2.78 | 4.91 | 3.78 | > 40 | > 100 |