Fig. 1
CSF2 (5q31.1) region, transcription factor binding sites and linkage disequilibrium. a and b Location of the CSF2 region on chromosome 5q31.1. CSF2 is 9379 bp and is composed of four exons. Chromosome position (build GRCh38.p13) for the selected SNPs under investigation; rs168681:G > A is located at 132066757, rs246835:T > C located at 132138332 [58]. c Linkage disequilibrium between the selected CSF2 SNPs rs168681:G > A and rs246835:T > C (D′ = 0.416, LOD = 4.32, r2 = 0.01). d CSF2 genotypes allele frequencies from the International HapMap project for Yoruba (YRI; Nigeria). Allele frequencies from the 1000 Genome project shows African (AFR) ancestry. Transcription factor binding analyses of the CSF2 gene variants. AFR African, YRI Yoruba, ER-alpha estrogen receptor alpha, ZEB1 zinc finger E-box binding homeobox 1, NF-X3 nuclear factor I-X3, USF2 upstream transcription factor 2, GATA GATA binding protein-1