Skip to main content

Table 1 IC50 and CC50 values of 5-ALA and 5-ALA with SFC against SARS-CoV-2 variants

From: Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 variants Compound IC50 (µM) CC50 (µM)
Wuhan 5-ALA 207  > 2000
  5-ALA/SFC 235/58.7  > 2000/> 500
Alpha 5-ALA 104  > 2000
  5-ALA/SFC 173/43.2  > 2000/> 500
Beta 5-ALA 1592  > 2000
  5-ALA/SFC 1311/327.7  > 2000/> 500
Gamma 5-ALA  > 2000  > 2000
  5-ALA/SFC 1516/379  > 2000/> 500
Delta 5-ALA  > 2000  > 2000
  5-ALA/SFC 397/99.2  > 2000/> 500
  1. In 5-ALA/SFC, the ratio of 5ALA to SFC was fixed as 4:1
  2. IC50 50% inhibition concentration, CC50 50% cytotoxicity concentration, 5-ALA 5-aminolevulinic acid, SFC sodium ferrous citrate