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Table 1 IC50 and CC50 values of 5-ALA and 5-ALA with SFC against SARS-CoV-2 variants

From: Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 variants

Compound

IC50 (µM)

CC50 (µM)

Wuhan

5-ALA

207

 > 2000

 

5-ALA/SFC

235/58.7

 > 2000/> 500

Alpha

5-ALA

104

 > 2000

 

5-ALA/SFC

173/43.2

 > 2000/> 500

Beta

5-ALA

1592

 > 2000

 

5-ALA/SFC

1311/327.7

 > 2000/> 500

Gamma

5-ALA

 > 2000

 > 2000

 

5-ALA/SFC

1516/379

 > 2000/> 500

Delta

5-ALA

 > 2000

 > 2000

 

5-ALA/SFC

397/99.2

 > 2000/> 500

  1. In 5-ALA/SFC, the ratio of 5ALA to SFC was fixed as 4:1
  2. IC50 50% inhibition concentration, CC50 50% cytotoxicity concentration, 5-ALA 5-aminolevulinic acid, SFC sodium ferrous citrate