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Table 4 Analysis of associated risk factors by meningitis type

From: Characteristics and biomarkers of patients with central nervous system infection admitted to a referral hospital in Northern Vietnam

Characteristics

Bacterial meningitis vs viral meningitis

Tubercular meningitis vs viral meningitis

Univariate analysis

Multivariate analysis#

Univariate analysis

Multivariate analysis#

Odds ratio (95% CI)

P value

Adjusted OR (95% CI)

P value

Odds ratio (95% CI)

P value

Adjusted OR (95% CI)

P value

Age, ≥40 years

3.1 (1.1–8.8)

0.034

2.6 (0.8–8.9)

0.134

3.9 (0.9–17.3)

0.078

6.6 (0.2–180)

0.265

Male sex

1.8 (0.6–5.2)

0.291

1.5 (0.4–5.8)

0.555

0.7 (0.2–2.9)

0.599

0.2 (0.1–4.0)

0.297

Place of residence, rural

3.7 (1.3–10.7)

0.015

4.1 (1.2–14.4)

0.030

5.7 (1.2–28.1)

0.032

1.5 (0.1–20.7)

0.769

Immunocompromised statea

2.9 (0.3–23.8)

0.332

  

8.0 (0.8–82.5)

0.081

10.1 (0.4–252)

0.159

Duration of fever at admission, ≥7 days

1.2 (0.4–3.5)

0.742

  

2.5 (0.6–10.9)

0.212

  

Neck stiffness

2.8 (1.0–8.1)

0.062

  

1.9 (0.4–8.0)

0.405

  

Lab findings

 Leukocytosis (≥10×109/L)

1.5 (0.5–4.4)

0.423

  

0.5 (0.1–2.1)

0.344

  

 Raised liver enzymes (AST>40 or ALT>35 U/L)

1.8 (0.7–5.1)

0.244

  

0.7 (0.2–2.9)

0.618

  

 Raised blood urea (>7.1 mmol/L)

2.5 (0.5–11.9)

0.258

  

5.3 (0.8–33.5)

0.076

5.5 (0.2–177)

0.336

 Raised CRP (≥1 mg/dL)

3.8 (1.2–11.7)

0.021

  

1.8 (0.4–8.2)

0.447

  

CSF analysis

 White blood cells (/μL), ≥100

4.1 (1.4–11.9)

0.009

  

4.6 (0.9–22.3)

0.059

  

 Neutrophil count (/μL), ≥50

4.1 (1.4–11.9)

0.009

  

3.1 (0.7–13.7)

0.137

  

 Protein (g/L), ≥1.0

8.7 (2.6–29.2)

<0.001

  

20.6 (3.2–133)

0.001

  

 CSF/blood glucose ratio, ≤40

27.6 (3.5–218.9)

0.002

  

25.2 (2.5–255)

0.006

  

 ADA (IU/L), ≥10

26.1 (3.3–206)

0.002

25.5 (3.1–212)

0.003

40.5 (3.9–417)

0.002

42.2 (2.0–882)

0.016

Abnormal CT/MRI

0.4 (0.1–1.8)

0.256

  

0.2 (0.1–1.1)

0.070

  
  1. #In multivariate analysis, variables with P value less than 0.2 in univariate analysis were included along with age and sex. Using backward stepwise method, the result of the final model was shown. Variables in CSF analysis were correlated, so we included only variable for ADA in the final multivariate model
  2. aThis includes diabetes mellitus, liver cirrhosis, HIV positive, renal diseases, cancer, liver diseases, and chronic alcoholic diseases