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Table 7 Liver and kidney biochemical analyses of the untreated, negative control and aqueous and ethanolic extract groups during acute toxicity experiments

From: Antioxidant and antimalarial properties of Sophora exigua Craib. root extract in Plasmodium berghei-infected mice

Parameter

Untreated

Negative

Aqueous extract

Ethanolic extract

Liver function tests

 AST (U/L)

143.50 ± 6.36

164.66 ± 3.33a

161.70 ± 8.30a

238.50 ± 2.50a

 ALT (U/L)

33.25 ± 4.45

28.44 ± 2.98

27.70 ± 3.70

42.00 ± 4.35a,b,c

 ALP (U/L)

84.50 ± 0.70

86.00 ± 3.05

80.55 ± 8.45

111.00 ± 7.02a,b,c

Kidney function tests

 BUN (mg/dL)

23.55 ± 0.21

24.00 ± 2.00

26.33 ± 2.08

31.00 ± 0.30a,b,c

 Creatinine (mg/dL)

0.55 ± 0.06

0.56 ± 0.02

0.55 ± 0.01

0.54 ± 0.02

  1. Data are the mean ± SD (n = 5 per group)
  2. ap < 0.05, significantly different compared to the untreated group
  3. bp < 0.05, significantly different compared to the negative control group
  4. cp < 0.05, significantly different compared to the aqueous extract group