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Table 4 Antimalarial activity of artesunate (a positive control), aqueous and ethanolic extracts

From: Antioxidant and antimalarial properties of Sophora exigua Craib. root extract in Plasmodium berghei-infected mice

Group

% Parasitemia

% Suppression

Infected untreated group

6.57 ± 1.89

-

Artesunate 6 mg/kg

0.18 ± 0.56

97.15 ± 0.92

Ethanolic extract 200 mg/kg

5.17 ± 0.89

29.60 ± 3.96 a,b

Ethanolic extract 400 mg/kg

4.62 ± 0.34

47.47 ± 0.38 a,c

Ethanolic extract 600 mg/kg

3.45 ± 0.03

53.09 ± 0.64 c

Aqueous extract 200 mg/kg

4.16 ± 0.33

36.64 ± 4.21c

Aqueous extract 400 mg/kg

3.14 ± 0.35

52.16 ± 3.77 c

Aqueous extract 600 mg/kg

2.59 ± 0.03

60.46 ± 0.38

  1. Data are presented as the mean ± SD (n = 5 per group)
  2. Data were analyzed by one-way ANOVA, followed by post hoc Tukey’s multiple comparison test
  3. ap < 0.05, significantly different compared to 600 mg/kg ethanolic extract
  4. bp < 0.05, significantly different compared to 200 mg/kg aqueous extract
  5. cp < 0.05, significantly different compared to 600 mg/kg aqueous extract
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Tropical Medicine and Health

ISSN: 1349-4147

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