From: Hyperferritinemia in children hospitalized with scrub typhus
N | Total (n = 72) | Survivors (n = 60) | Nonsurvivors (n = 12) | P value | |
---|---|---|---|---|---|
Parameter | |||||
Age, months | 72 | 60 (36, 96) | 60 (30, 98) | 36 (31, 105) | 0.60 |
Boys, n (%) | 72 | 45 (62.5) | 41 (68.3) | 4 (33.3) | 0.04 |
PRISM III | 72 | 8 (5, 12) | 8 (5, 11) | 12 (8.7, 17.5) | 0.005 |
Duration of illness, days | 72 | 7 (5, 10) | 7 (5, 9.5) | 9 (5, 12) | 0.38 |
Investigations | |||||
Ferritin, μg/L | 62 | 668 (420, 2714) | 666 (382, 2653) | 1806 (443, 4727) | 0.53 |
Normal (< 500), n (%) | 17 (27.4) | 15 (28.8) | 2 (20) | 0.42 | |
Mild (> 500–2000), n (%) | 26 (41.9) | 23 (44.2) | 3 (30) | ||
Moderate (> 2000–10,000), n (%) | 13 (21) | 10 (19.2) | 3 (30) | ||
Severe (> 10,000), n (%) | 6 (9.7) | 4 (7.8) | 2 (20) | ||
Hemoglobin, g/dl | 72 | 8.7 (7.4, 10.2) | 8.6 (7.5, 10.5) | 8.1 (6.8, 10.1) | 0.48 |
Total leukocyte count cells/mm3 | 72 | 14,000 (9820, 18,000) | 14,090 (10,200, 17,500) | 12465 (7020, 21,080) | 0.39 |
Platelet count cells/mm3 | 72 | 18,000 (44,000, 80,000) | 19,000 (48,000, 80,000) | 31000 (11,500, 100,000) | 0.39 |
Albumin, g/dl | 58 | 2.2 (2.1, 2.6) | 2.3 (2.1, 2.6) | 2.1 (1.9, 2.2) | 0.05 |
Severe hypoalbuminemia (< 2.5 g/dl), n (%) | 58 | 39 (54.2) | 30 (50) | 9 (75) | 0.14 |
Lactate, mmol/L | 72 | 1.6 (1.1, 2.6) | 1.6 (1, 1.8) | 3.0 (1.85, 9.8) | 0.04 |
Organ dysfunction | |||||
Hematological dysfunction, n (%) | 72 | 68 (94.4) | 56 (93.3) | 12 (100) | 0.60 |
Respiratory failure, n (%) | 72 | 40 (55.5) | 28 (46.6) | 12 (100) | 0.001 |
ARDS, n (%) | 72 | 23 (31.9) | 13 (21.7) | 10 (83.3) | < 0.0001 |
Mechanical ventilation, n (%) | 72 | 34 (47.2) | 22 (36.7) | 12 (100) | 0.0001 |
Shock, n (%) | 72 | 20 (28.2) | 12 (20.3) | 8 (66.7) | 0.003 |
VIS on day 1 | 72 | 0 (0, 10) | 0 (0,0) | 10 (0,30) | 0.0001 |
AKI, n (%) | 72 | 15 (20.8) | 10 (16.7) | 5 (41.7) | 0.02 |
RRT, n (%) | 72 | 5 (6.9) | 2 (3.3) | 3 (25) | 0.03 |
CNS dysfunction, n (%) | 72 | 10 (13.9) | 6 (10) | 4 (33.3) | 0.05 |
Coagulopathy (INR > 1.5), n (%) | 56 | 12 (21.4) | 10 (21.3) | 2 (22.2) | 1.0 |
PELOD-2 score | |||||
Day 1 | 72 | 3 (2, 7) | 2 (2, 5) | 7 (7, 9) | < 0.0001 |
Day 2 | 67 | 2 (1, 5) | 2 (1, 5) | 6 (4, 7) | 0.001 |
Day 3 | 64 | 2 (1, 5) | 2 (1, 4) | 4 (1, 6) | 0.32 |