Sensitivity and specificity of tuberculosis signs and symptoms screening and adjunct role of social pathology characteristics in predicting bacteriologically confirmed tuberculosis in Myanmar

Table 2 Sensitivity, specificity, and positive likelihood ratio of various combinations of TB-SS by using bacteriologically confirmed TB as the gold standard

Category^a	Cough	Hemoptysis	Recent weight loss	Chest pain	Fever	Total (N)	Bacteriologically confirmed TB						Positive likelihood ratio
							Positive (N = 311)			Negative (N = 51,056)
							n	Sensitivity (%)	95% CI	n	Specificity (%)	95% CI
1	Any TB signs and symptom					16,934	186	59.8	54.1–65.3	16,748	67.2	66.7–67.6	1.8
2	+	-	-	-	-	7306	76	24.4	19.7–29.6	7230	85.8	85.5–86.1	1.7
3	-	-	-	+	-	2861	8	2.6	1.1–5.0	2853	94.4	94.2–94.6	0.5
4	+	-	-	+	-	2312	26	8.4	5.5–12.0	2286	95.5	95.3–95.7	1.8
5	+	-	-	-	+	1005	12	3.9	2.0–6.6	993	98.1	97.9–98.2	1.9
6	-	-	-	-	+	819	9	2.9	1.3–5.4	810	98.4	98.3–98.5	1.7
7	+	-	-	+	+	598	11	3.5	1.7–6.2	587	98.9	98.7–98.9	1.8
8	-	-	+	-	-	410	8	2.6	1.1–5.0	402	99.2	99.1–99.3	3.2
9	+	-	+	+	-	401	8	2.6	1.1–5.0	393	99.5	99.4–99.6	3.3
10	-	-	-	+	+	299	1	0.3	0.0–1.7	298	99.4	99.3–99.5	0.5
11	-	-	+	+	-	168	0	0	0.0–1.1	168	99.6	99.5–99.7	0.0

“+” presence, “-” absence, 95% CI 95% confidence interval (Bootstrap resampling = 500)
^aThe remaining 21 categories, which had a sensitivity of < 10% and specificity of ~ 99%, are not shown

ISSN: 1349-4147