Skip to main content

Table 4 Selectivity indices of some antitubercular plant species reported in East Africa

From: Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Plant

Solvent

MIC on Mtb strain (μg/ml)

IC50 (μg/ml)

SI

Comment

Commiphora edulis

Dichloromethane

1560

393

0.25

More toxic to human cells than the Mtb; not useful

Ethyl acetate

3125

1734

0.55

More toxic to human cells than the Mtb; not useful

Commiphora ellenbeckii

Water

780

1509

1.93

More toxic to Mtb than human cells but the SI is low. May be optimized for lead candidate identification

Methanol

3125

608

0.19

More toxic to human cells than the Mtb; not useful

Commiphora mildbraedii

Methanol

390

452

1.16

More toxic to Mtb than human cells but the SI is close to 1. No practical application

Ethyl acetate

6250

339

0.054

More toxic to human cells than the Mtb; not very useful

Khaya senegalensis

Chloroform

6.25

1000

160

More toxic to Mtb than human cells with high SI. Promising for development of lead candidate

Rosmarinus officinalis L.

Chloroform

6.25

100

16

More toxic to Mtb than human cells with high SI. Promising for development of lead candidate

  1. IC50 cytotoxic concentration normal cells, SI selectivity index