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Table 4 Selectivity indices of some antitubercular plant species reported in East Africa

From: Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Plant Solvent MIC on Mtb strain (μg/ml) IC50 (μg/ml) SI Comment
Commiphora edulis Dichloromethane 1560 393 0.25 More toxic to human cells than the Mtb; not useful
Ethyl acetate 3125 1734 0.55 More toxic to human cells than the Mtb; not useful
Commiphora ellenbeckii Water 780 1509 1.93 More toxic to Mtb than human cells but the SI is low. May be optimized for lead candidate identification
Methanol 3125 608 0.19 More toxic to human cells than the Mtb; not useful
Commiphora mildbraedii Methanol 390 452 1.16 More toxic to Mtb than human cells but the SI is close to 1. No practical application
Ethyl acetate 6250 339 0.054 More toxic to human cells than the Mtb; not very useful
Khaya senegalensis Chloroform 6.25 1000 160 More toxic to Mtb than human cells with high SI. Promising for development of lead candidate
Rosmarinus officinalis L. Chloroform 6.25 100 16 More toxic to Mtb than human cells with high SI. Promising for development of lead candidate
  1. IC50 cytotoxic concentration normal cells, SI selectivity index