Table 1 Inhibitory effect of febrifugine on the daily egg output of six paired Schistosoma mansoni adult worms within 7 days
From: In vitro effects of febrifugine on Schistosoma mansoni adult worms
Febrifugine concentration (μg/ml) | Mean daily egg output (± standard error) | |||||||
|---|---|---|---|---|---|---|---|---|
Day 0 | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | |
Experiment 1 | ||||||||
0 (control) | 30.0 ± 9.9 | 115.3 ± 16.3 | 111.2 ± 18.2 | 52.8 ± 14.3 | 47.2 ± 17.6 | 36.5 ± 12.9 | 7.3 ± 4.2 | 5.7 ± 3.3 |
0.05 | 20.2 ± 5.8 | 102.2 ± 13.8 | 81.0 ± 19.8 | 43.3 ± 3.8 | 4.8 ± 3.1a | 0.3 ± 0.3b | 0 | |
0.1 | 19.7 ± 9.2 | 101.3 ± 16.1 | 74.5 ± 7.8 | 35.8 ± 3.0 | 1.2 ± 0.3b | 0 | ||
0.2 | 24.7 ± 10.5 | 51.5 ± 17.5 | 68.8 ± 29.6 | 18.0 ± 9.1 | 0.8 ± 0.5b | 0.2 ± 0.2b | 0 | |
0.5 | 18.3 ± 6.0 | 85.3 ± 20.3 | 50.7 ± 15.5 | 4.5 ± 2.5b | 1.2 ± 0.8b | 0 | ||
Experiment 2 | ||||||||
0 (control) | 26.5 ± 12.6 | 94.2 ± 18.8 | 101.2 ± 21.6 | 98.3 ± 18.9 | 57.5 ± 14.8 | 22.0 ± 6.6 | 8.7 ± 2.4 | 4.8 ± 1.9 |
0.005 | 20.3 ± 6.3 | 92.0 ± 18.3 | 69.0 ± 15.1 | 88.7 ± 29.0 | 66.2 ± 26.1 | 13.2 ± 6.1 | 6.7 ± 2.6 | 1.7 ± 0.8 |
0.01 | 25.3 ± 10.1 | 86.5 ± 5.9 | 78.8 ± 15.8 | 80.0 ± 15.4 | 48.0 ± 21.3 | 6.8 ± 5.7 | 1.7 ± 1.5 | 0.7 ± 0.4 |
0.02 | 16.8 ± 7.2 | 100.2 ± 28.5 | 89.5 ± 13.9 | 84.7 ± 29.8 | 12.0 ± 5.4a | 1.7 ± 0.9a | 0 | |