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Table 4 Poisson regression with multilevel analysis, with health facility as cluster variable in Northern Tanzania. Interaction effects for mortality among patients with HIV adjusted for the significant effects included in Table 3 (N = 82,925)

From: Effect of tuberculosis infection on mortality of HIV-infected patients in Northern Tanzania

Characteristics

ARR (95%CI) PLHIV without TB

ARR (95%CI)

PLHIV/TB co-infection *

Effect of TB infection in baseline **

Age

 15–24

1

 

2.06 (1.42–2.99)

 25–34

1.27 (1.07–1.52)

0.97 (0.66–1.43)

 35–44

1.36 (1.14–1.61)

0.91 (0.63–1.33)

 45–55

1.34 (1.12–1.60)

0.93 (0.63–1.37)

 Above 55

1.98 (1.65–2.37)

1.26 (0.84–1.90)

Sex

 Male

1

 

1.41 (1.22–1.62)

 Female

0.57 (0.53–0.61)

0.63 (0.53–0.75)

Body weight

 Below 40 kg

1

 

0.89 (0.70–1.13)

 40–60 kg

0.46 (0.42–0.52)

0.80 (0.62–1.02)

 Above 60 kg

0.22 (0.20–0.26)

0.58 (0.42–0.80)

HIV WHO stage

 Stage 1

1

 

1.49 (1.01–2.19)

 Stage 2

1.35 (1.19–1.53)

1.53 (0.99–2.36)

 Stage 3

1.50 (1.33–1.68)

1.42 (0.96–2.09)

 Stage 4

2.22 (1.95–2.54)

1.74 (1.16–2.62)

Region

 Arusha

1

 

2.02 (1.58–2.59)

 Kilimanjaro

0.89 (0.77–1.03)

0.63 (0.46–0.86)

 Tanga

0.86 (0.76–0.97)

0.61 (0.48–0.78)

Functional status

 Bedridden

1

 

1.15 (0.90–1.48)

 Ambulatory

2.57 (1.88–3.52)

1.11 (0.54–2.31)

 Working

0.59 (0.52–0.67)

0.81 (0.64–1.03)

Nutritional status

 Ok

1

 

1.61 (1.45–1.79)

 Moderate

1.67 (1.50–1.86)

1.28 (1.03–1.61)

 Severe

2.40 (1.71–3.35)

0.63 (0.35–1.12)

Year of follow-up

 2012

1

 

1.36 (1.05–1.74)

 2013

0.83 (0.74–0.93)

0.87 (0.63–1.20)

 2014

0.73 (0.65–0.82)

0.91 (0.68–1.24)

 2015

0.71 (0.64–0.80)

0.71 (0.52–0.97)

 2016

0.56 (0.50–0.63)

0.46 (0.33–0.64)

 2017

0.44 (0.38–0.51)

0.72 (0.51–1.01)

  1. ARR adjusted rate ratio
  2. Estimates of interaction effects are adjusted for age, sex, bodyweight, HIV WHO stage, region, functional status, and year of follow-up
  3. *At non-baseline levels the effects are shown within each group (HIV alone and HIV/TB) comparing the level with the baseline level
  4. **Adjusted rate ratios in the baseline level of each factor show the effect of TB on mortality at that baseline level