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Table 1 IC50 and selectivity index of IVM

From: Evaluation of the inhibitory effect of ivermectin on the growth of Babesia and Theileria parasites in vitro and in vivo

Compound

Babesia and Theileria

IC50 (μM)a

EC50 (μM)b

Selective indicesc

MDBK

NIH/3 T3

HFF

MDBK

NIH/3 T3

HFF

IVM

B. bovis

53.3 ± 4.8

138.9 ± 4.9

283.8 ± 3.6

287.5 ± 7.6

2.6

5.3

5.4

B. bigemina

98.6 ± 5.7

138.9 ± 4.9

283.8 ± 3.6

287.5 ± 7.6

1.4

2.9

2.9

B. divergens

30.1 ± 2.2

138.9 ± 4.9

283.8 ± 3.6

287.5 ± 7.6

4.6

9.4

9.6

B. caballi

43.7 ± 3.7

138.9 ± 4.9

283.8 ± 3.6

287.5 ± 7.6

3.2

6.5

6.6

T. equi

90.1 ± 8.1

138.9 ± 4.9

283.8 ± 3.6

287.5 ± 7.6

1.5

3.1

3.2

  1. aHalf-maximal inhibition concentration of ivermectin on the in vitro culture of parasites. The value was determined from the dose-response curve using nonlinear regression (curve fit analysis). The values are the means of triplicate experiments
  2. bHalf-maximal effective concentration of ivermectin on cell lines. The values were determined from the dose-response curve using nonlinear regression (curve fit analysis). The values are the means of triplicate experiments
  3. cRatio of the EC50 of cell lines to the IC50 of each species. High numbers are favorable
  4. IVM ivermectin, MDBK Madin–Darby bovine kidney, NIH/3 T3 Mouse embryonic fibroblast, HFF Human foreskin fibroblast