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Table 3 Effect of food and parasite infection on the oral absorption of N-251 in mice

From: Pharmacokinetic analysis of new synthetic antimalarial N-251

Conditions Pharmacokinetic parameters
Cmax (ng/mL) Tmax (h) AUCpo (ng/mL·h) F MRTpo (h)
Normal-fasted (control) 1677.33 ± 811.23 2 3768.25 0.2277 2.46
Infected-fasted 1767.17 ± 1649.75 2 3273.35 0.1978 2.45
Normal-fed 952.50 ± 332.49 1.5 2282.17 0.1379 3.01
  1. The Cmax with SD and Tmax were the observed values. AUC and MRT were calculated from 0 to infinity using the trapezoidal rule. F was calculated utilizing the AUC value of 2433.64 ng/mL·h after the intravenous administration of 10 mg/kg