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Table 3 Effect of food and parasite infection on the oral absorption of N-251 in mice

From: Pharmacokinetic analysis of new synthetic antimalarial N-251

Conditions

Pharmacokinetic parameters

Cmax (ng/mL)

Tmax (h)

AUCpo (ng/mL·h)

F

MRTpo (h)

Normal-fasted (control)

1677.33 ± 811.23

2

3768.25

0.2277

2.46

Infected-fasted

1767.17 ± 1649.75

2

3273.35

0.1978

2.45

Normal-fed

952.50 ± 332.49

1.5

2282.17

0.1379

3.01

  1. The Cmax with SD and Tmax were the observed values. AUC and MRT were calculated from 0 to infinity using the trapezoidal rule. F was calculated utilizing the AUC value of 2433.64 ng/mL·h after the intravenous administration of 10 mg/kg