Survey on synergism effect of ketotifen in combination with pyrimethamine in treatment of acute murine toxoplasmosis

Table 1 Anti-Toxoplasma activity of KET and control groups in brain tissue in the pre-treatment groups

Drug/dose, mg	CT (mean ± SD)	Parasite load	P value
KET
2	28.26 ± 0.77	15,698	P < 0.001
3	24.53 ± 0.06	72,898	P < 0.001
KET and PYR
2 + 50	23.37 ± 1.15	100,597	P < 0.001
3 + 50	22.42 ± 1.39	196,591	P < 0.001
PYR (positive control)
50	25.28 ± 0.82	30,572	P < 0.001
PBS (negative control)	21.12 ± 0.34	865,548	–

ISSN: 1349-4147