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Table 1 Antiviral activity of BFA against DENV-1 to 4, ZIKV, and JEV in Vero cell

From: Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses

IC50 (nM)a CC50 (nM)b
DENV-1 DENV-2 DENV-3 DENV-4 ZIKV JEV  
61.3 ± 13.5 54.6 ± 0.9 57.9 ± 0.1 65.7 ± 6.3 54.8 ± 0.4 58.4 ± 0.3 2000
  1. All calculation was performed by using GraphPad Prism software. All values are the results from two independent experiments
  2. aIC50—50% inhibitory concentration of BFA were calculated from the results of the virus titer determined by focus-forming assay
  3. bCC50—50% cytotoxic concentration of BFA were calculated from the dose-response curve