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Table 1 Cross-reactivities of anti-artesunate (ART) polyclonal antibodies with ART and related antimalarial drugs

From: Development of a simple and specific direct competitive ELISA for the determination of artesunate using an anti-artesunate polyclonal antiserum

ART and related antimalarial drugs 50 % inhibitory concentrationb (ng/ml) Cross-reactivityc (%)
ART 2.3 100
Artemisinina 2000 0.12
Dihydroartemisinina 5200 0.04
Quininea >104 <0.023
Chloroquine >104 <0.023
Primaquine >104 <0.023
Mefloquinea >104 <0.023
Amodiaquine >104 <0.023
Pyrimethaminea >104 <0.023
Sulfadiazine >104 <0.023
  1. aTest compound solutions contained 0.5 % dimethylformamide at a concentration of 104 ng/ml
  2. bConcentrations of test compounds were expressed as free base
  3. cCross-reactivity of anti-ART antibodies for ART-related antimalarial drugs was determined by dividing the 50 % inhibitory concentration (IC50) of ART by the IC50 values of each antimalarial drug and expressed as a percentage