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Fig. 5 | Tropical Medicine and Health

Fig. 5

From: Development and utility of an in vitro, fluorescence-based assay for the discovery of novel compounds against dengue 2 viral protease

Fig. 5

Cell-based assays. a Cell viability assay. Effect of compounds on cell viability was observed via the MTT assay. Results are expressed as percentage of live cells relative to vehicle (1 % DMSO) control. b Cell-based infectivity assay of compounds. Selected compounds were examined at different concentrations and evaluated for antiviral effect on Vero cells. Activity is reported as percentage relative to infected vehicle-treated only control. c Antigen detection ELISA. Effect of the different compounds on the detected viral antigens in culture fluid was examined. Results are expressed as percentage relative to infected vehicle-treated only control. Statistical analysis involved two-way ANOVA with Bonferroni correction. Error bars indicate SD

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