Table 2 Screening IC50 values of nutritional supplements against T. b. brucei and mammalian cells in vitro
Supplement | T. b brucei a | Mammalian cells | |||
|---|---|---|---|---|---|
Jurkat cells | SI | Vero cells | SI | ||
5-Aminolevrinic acid | 51.3 μM | >100 μM | >1.95 | >100 μM | >1.95 |
Catechin hydrate | 53.6 | >100 | >1.86 | >100 | >1.86 |
Coenzyme Q10 | >100 | >100 | ND | >100 | ND |
Epigallocatechin gallate | 8.40 | 35.7 | 4.25 | 39.8 | 4.74 |
Polyphenon-60 | 16.9 | 26.4 | 1.56 | 41.2 | 2.44 |
Vitamin C | 58.6 | >100 | >1.70 | >100 | >1.70 |
Vitamin D3 | 4.58 | >100 | >21.8 | >100 | >21.8 |
Vitamin E | 28.6 | >100 | >3.49 | >100 | >3.49 |
Curcumin | 6.05 | 34.3 | 5.66 | 90.4 | >1.70 |
Suramin | 1.18 | >100 | >84.8 | >100 | >84.8 |