Skip to main content

Advertisement

Table 2 Screening IC50 values of nutritional supplements against T. b. brucei and mammalian cells in vitro

From: Anti-trypanosome effects of nutritional supplements and vitamin D3: in vitro and in vivo efficacy against Trypanosoma brucei brucei

Supplement T. b brucei a Mammalian cells
Jurkat cells SI Vero cells SI
5-Aminolevrinic acid 51.3 μM >100 μM >1.95 >100 μM >1.95
Catechin hydrate 53.6 >100 >1.86 >100 >1.86
Coenzyme Q10 >100 >100 ND >100 ND
Epigallocatechin gallate 8.40 35.7 4.25 39.8 4.74
Polyphenon-60 16.9 26.4 1.56 41.2 2.44
Vitamin C 58.6 >100 >1.70 >100 >1.70
Vitamin D3 4.58 >100 >21.8 >100 >21.8
Vitamin E 28.6 >100 >3.49 >100 >3.49
Curcumin 6.05 34.3 5.66 90.4 >1.70
Suramin 1.18 >100 >84.8 >100 >84.8
  1. ND not determined, SI selectivity index
  2. a T. b. brucei GUTat 3.1 strain was used