Anti-trypanosome effects of nutritional supplements and vitamin D 3 : in vitro and in vivo efficacy against Trypanosoma brucei brucei

Table 1 Supplements and chemicals selected for in vitro screening of T. b. brucei

Chemical name	Molecular weight (g/mol)	Function
Polyphenon-60	290.3	Mainly anti-oxidative effects and also anti-cancer, anti-inflammatory [31]
Catechin hydrate	290.3	Able to impart thermal stability to collagen [32]
Epigallocatechin gallate	458.4	Modulates cognitive function and brain activity [33]
5-Aminolevrinic acid	167.6	Helps in heme synthesis, heme protein design [34]
Coenzyme Q₁₀	863.34	Act as an anti-oxidant, needed for basic cellular function [35]
Vitamin C	198.11	An anti-oxidant, required for collagen synthesis and biosynthesis of certain hormones [36]
Vitamin D₃	384.64	An immunomodulator, supports the brain and nervous system [37]
Vitamin E	430.71	Essential for neurological function [38]
Curcumin	368.38	Exhibits anti-cancer, chemo- preventive, chemo- and radio-sensitization properties [39]