Variants | Total | Aparasitemic (MPS negative) | Non-SMA (Hb ≥ 5.0 g/dL) | SMA (Hb < 5.0 g/dL) | P value |
---|---|---|---|---|---|
No. of participants | 1203 | 250 | 772 | 181 | |
CSF2:g.-7032 G > A (rs168681:G > A) genotype | |||||
 GG | 636 (52.87) | 134 (53.60) | 407 (52.72) | 95 (52.49) | 0.9972a |
 GA | 476 (39.57) | 98 (39.20) | 305 (39.51) | 73 (40.33) | |
 AA | 91 (7.56) | 18 (7.20) | 60 (7.77) | 13 (7.18) | |
 P value | 0.8847 | 1.0000 | 0.7869 | 1.0000 | |
 Allele frequency (p/q) | 0.727/0.273 | 0.732/0.268 | 0.725/0.275 | 0.726/0.274 | |
 HWE, P value | 0.8847 | 1.0000 | 0.7869 | 1.0000 | |
CSF2:g.64544T > C (rs246835:T > C) genotype | |||||
 TT | 984 (81.80) | 196 (78.40) | 636 (82.38) | 152 (83.98) | 0.2202a |
 TC | 125 (10.39) | 35 (14.00) | 77 (9.97) | 13 (7.18) | |
 CC | 94 (7.81) | 19 (7.60) | 59 (7.64) | 16 (8.84) | |
 P value | 2.6077 × 10–55 | 2.0014 × 10–09 | 1.9886 × 10–36 | 2.6515 × 10–13 | |
 Allele frequency (p/q) | 0.870/0.130 | 0.854/0.146 | 0.874/0.126 | 0.876/0.124 | |
 HWE, P value | 2.6182 × 10–55 | 2.0014 × 10–9 | 1.9896 × 10–36 | 2.6528 × 10–13 | |
CSF2:g.-7032 G > A (rs168681:G > A)/CSF2:g.64544T > C (rs246835:T > C) haplotypes | |||||
 GT | 1470 (61.10) | 297 (59.40) | 949 (61.50) | 224 (61.90) | 0.5565a |
 GC | 278 (11.60) | 69 (13.80) | 170 (11.00) | 39 (10.80) | |
 AT | 623 (25.90) | 130 (26) | 400 (25.90) | 93 (25.70) | |
 AC | 35 (1.50) | 4 (0.80) | 25 (1.60) | 6 (1.70) | |
 LE, P value | 1.6781 × 10–13 | 1.2543 × 10–06 | 2.0835 × 10–07 | 0.0307 | |
CSF2:g.-7032 G > A (rs168681:G > A)/CSF2:g.64544T > C (rs246835:T > C) diplotypes | |||||
 GT/GT | 500 (41.56) | 93 (37.20) | 331 (42.88) | 76 (41.99) | 0.3255a |
 GT/GC | 71 (5.90) | 25 (10.00) | 38 (4.92) | 8 (4.42) | |
 GC/GC | 65 (5.40) | 16 (6.40) | 38 (4.92) | 11 (6.08) | |
 GT/AT | 399 (33.17) | 86 (34.40) | 249 (32.25) | 64 (35.36) | |
 GT/AC | 27 (2.24) | 3 (1.20) | 19 (2.46) | 5 (2.76) | |
 GC/AC | 85 (7.07) | 17 (6.80) | 56 (7.25) | 12 (6.63) | |
 AT/AT | 50 (4.16) | 9 (3.60) | 37 (4.79) | 4 (2.21) | |
 AT/AC | 4 (0.33) | 1 (0.40) | 2 (0.26) | 1 (0.55) | |
 AC/AC | 2 (0.17) | 0 (0.00) | 2 (0.26) | 0 (0.00) |